(Rosenberg, W. & Donald, A. (1995). Evidence based medicine: An approach to clinical problem-solving. BMJ, 310, 1122-1126).
Use PICOS to develop a clear idea what information you are seeking.
P – Population/Patient/Problem
I – Intervention
C – Comparison
O – Outcome
S – Setting/Study type
(T) – Time
P: For what group do you need information?
I: What medical intervention do you need to study the effect of?
C: What is the evidence that the intervention produces different results than another intervention or no intervention?
O: What is the effect of the intervention?
S: What is the research setting (e.g., ambulatory setting) or type of study (e.g., RCT)?
T: Is there a timeframe for the outcome?